Risk Assessment

Personal Information

Patient Eligibility

Does the woman undergoing risk assessment have a history of breast cancer or ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS)?

A history of breast cancer or ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) increases the risk of developing invasive breast cancer. The method used by the breast cancer risk assessment tool to calculate invasive breast cancer risk is not fully accurate for those with a history of DCIS/LCIS. Additionally, the tool cannot accurately predict the risk of developing new cancers for those with a history of breast cancer.

Is the woman undergoing risk assessment diagnosed with a BRCA1 or BRCA2 gene mutation or a genetic syndrome that would increase the risk of breast cancer?

Demography

What is the age of the woman who will be risk assessed?(This tool only calculates risk for women aged 35 and over.)

The risk of developing breast cancer increases with age. The majority of breast cancer cases occur after age 50. Cancers often develop slowly over time. Therefore, breast cancer is more common among older women.

Note: This tool only calculates risk for women aged 35 and over

What is the race of the woman who will be risk assessed? ?

8a. What is the sub-race of the woman who will be risk assessed?

Patient and Family History

Has the woman undergoing risk assessment ever had a breast biopsy?

The risk for women who have a breast biopsy depends on many factors, including age at first live birth and family history. The relationship of these two factors in white women is shown in the relative risks table below.

7a. How many breast biopsies (positive or negative) have you had before?

7b. Is there at least one biopsy that detected atypical hyperplasia?

What is the first menstrual age of the woman to be assessed for risk?

Women who first menstruate before age 12 have a slightly increased risk of breast cancer. Levels of the female hormone estrogen change with the menstrual cycle. The slightly higher risk of breast cancer in women who begin menstruating at a very early age may be due to their longer lifespan under the influence of estrogen.

What is the age at which the woman to be risk assessed had her first live birth?

Risk depends on many factors, including age at first live birth and family history. The relationship between these two factors in white women is shown in the relative risk table below.
Relative risks of developing breast cancer*

Age at First Live Birth	Number of Relatives with Breast Cancer
Age at First Live Birth	0	1	2 or more
20 or younger	1	2.6	6.8
20-24	1,2	2.7	5.8
25-29 or childless	1.5	2.8	4.9
30 or older	1.9	2.8	4.2

In women with 0 or 1 first-degree relative with breast cancer, the risk increases with age at first live birth. In women with 2 or more first-degree relatives with breast cancer, the risk decreases with age at first live birth.

*Adapted from Table 1 Gail MH, Brinton LA, Byar DP, Corle DK, Green SB, Shairer C, Mulvihill JJ: Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 81(24):1879-86, 1989. [PubMed Abstract]

How many first-degree relatives (mother, sister, daughter) of the woman to be risk assessed have had breast cancer?

Having one or more first-degree relatives (mother, sister, daughter) with breast cancer increases a woman's likelihood of developing breast cancer.

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Breast MRI is the most sensitive method for detecting breast cancer early.

Risk Assessment